{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Mehdi Hazari", "hasEmail": "mailto:hazari.mehdi@epa.gov"}, "description": "Cardiac and ventilatory physiological data for mice exposed to acrolein. \n\nThis dataset is associated with the following publication:\nKurhanewicz, N., A. Ledbetter, A. Farraj, and M. Hazari. TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice.   TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 347: 104-114, (2018).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/Autonomic%20Redo%20Ventilatory%20Data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Autonomic Redo Ventilatory Data.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/Autonomic%20Redo_effective%20dose.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Autonomic Redo_effective dose.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/Autonomic%20redo%20HRV.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Autonomic redo HRV.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/Autonomic%20redo%20HRV_KO.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Autonomic redo HRV_KO.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/HRV%20Redo%20BAL%20and%20GPX%20data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "HRV Redo BAL and GPX data.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1407607/HRV_compiled_first%20drug%20administration.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "HRV_compiled_first drug administration.xlsx"}], "identifier": "https://doi.org/10.23719/1407607", "keyword": ["MICE", "TRPA1", "air pollution", "autonomic", "cardiovascular", "heart rate variability", "reflex", "ventilatory function"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2016-01-31", "programCode": ["020:094"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.taap.2018.03.027"], "rights": null, "title": "Role of TRPA1 in acrolein cardiac effects in mice"}