{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Recent studies have described the spontaneous development of\t\t\t arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred\t\t\t on specific and different genetic backgrounds. The levels of both secreted and\t\t\t intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the\t\t\t arterial wall may not be adequate to effectively inhibit the excess amounts of\t\t\t locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may\t\t\t predispose to local inflammatory disease in particular tissues in the presence\t\t\t of other as yet unknown genetically influenced factors.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130011/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/rtpz-qkpv", "issued": "2025-07-14", "keyword": ["cytokine-research", "il-1ra", "nih", "rheumatoid-arthritis", "vasculitis"], "landingPage": "https://healthdata.gov/d/rtpz-qkpv", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Physiologic role of interleukin-1 receptor antagonist"}