{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Urmila Kodavanti", "hasEmail": "mailto:kodavanti.urmila@epa.gov"}, "description": "In this study, using male Wistar and Wistar-derived Goto-Kakizaki (GK) rats, which exhibit a non-obese type-2 diabetes phenotype, we investigated whether two key metabolic stressors, type-2 diabetes and a high-cholesterol atherogenic diet, exacerbate ozone-induced metabolic effects. Rats were fed a normal control diet (ND) or high-cholesterol diet (HCD) for 12 weeks starting at 4 week-age and then exposed to filtered air or 1.0-ppm ozone (6h/day) for 1 or 2 days. Metabolic responses were analyzed at the end of each day and after an 18-hour recovery period following the 2-day exposure. \n\nThis dataset is associated with the following publication:\nSnow, S., A. Henriquez, A. Fisher, B. Vallanat, J. House, M.C. Schladweiler, C. Wood, and U. Kodavanti. Peripheral Metabolic Effects of Ozone Exposure in Healthy and Diabetic Rats on Normal or High-Cholesterol Diet.   TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115427): 1, (2021).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1521138/Metabolic%20Paper%20Science%20Hub-final.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Metabolic Paper Science Hub-final.xlsx"}], "identifier": "https://doi.org/10.23719/1521138", "keyword": ["Ozone", "Western high-cholesterol diet", "adipose tissue", "liver", "metabolic response", "type-2 diabetes rat model"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2020-11-30", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.taap.2021.115427"], "rights": null, "title": "Peripheral Metabolic Effects of Ozone Exposure in Healthy and Diabetic Rats on Normal or High-Cholesterol Diet"}