{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Leah Wehmas", "hasEmail": "mailto:wehmas.leah@epa.gov"}, "description": "Gene expression data on >20 year-old, paired frozen and archival FFPE liver samples generated using targeted resequencing (TempO-Seq) and whole-genome RNA-sequencing methods. Samples were originally collected from male mice exposed to a reference chemical (dichloroacetic acid, DCA) at 0, 198, 313 and 427 mg/kg-day, (n=6/dose) by drinking water for 6 days. Portions of this dataset are inaccessible because: Including all of these files on ScienceHub would exceed the 1 Gb limit. They can be accessed through the following means: The data is stored on the L: Drive. Information on all of the files and file paths are indicated in the 20210923_Readme.xlsx file uploaded with the data. Format: Excel files, tab delimited files, csv files, and sequencing FASTQ files. \n\nThis dataset is associated with the following publication:\nCannizzo, M., C. Wood, S. Hester, and L. Wehmas. Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action.   Toxicology Reports. Elsevier B.V., Amsterdam,  NETHERLANDS, 9: 883-894, (2022).", "distribution": [{"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78962", "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78962"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1523143/20210908_DCA9402_Additional_Data.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "20210908_DCA9402_Additional_Data.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1523143/20210908_DCA9402_MS_tables.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "20210908_DCA9402_MS_tables.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1523143/20210923_Readme.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "20210923_Readme.xlsx"}], "identifier": "https://doi.org/10.23719/1523143", "keyword": ["Formalin-fixed paraffin-embedded (FFPE)", "RNA-sequencing", "benchmark dose analysis", "dichloroacetic acid"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2021-09-23", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1212/nxi.0000000000001078"], "rights": null, "title": "Targeted RNA-sequencing of aged FFPE liver tissue data"}