{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Gerald Ankley", "hasEmail": "mailto:ankley.gerald@epa.gov"}, "description": "This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations would result in elevated plasma 17\u03b2-estradiol concentrations in the fish. Secondly, we sought to establish whether observed elevations in plasma 17\u03b2-estradiol occurred as a result of the conversion of external estrone by the fish using an approach involving exposure of the fish to 13C-labeled estrone. Endpoints reported in the dataset include plasma 17\u03b2-estradiol and estrone concentrations, plasma vitellogenin concentrations, hepatic vitellogenin mRNA, 13C-labeled plasma 17\u03b2-estradiol and estrone concentrations, and testicular and/or hepatic expression of aromatase and several hydroxysteroid dehydrogenases involved in estrone metabolism. \n\nThis dataset is associated with the following publication:\nAnkley, G., D. Feifarek, B. Blackwell, J. Cavallin, K. Jensen, M. Kahl, S. Poole, E. Randolph, T. Saari, and D. Villeneuve. Reevaluating the significance of estrone as an environmental estrogen (article).   ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 51: 4705-4713, (2017).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1369435/AnkleyGerald_A-cjt8_Dataset%20Estrone.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "AnkleyGerald_A-cjt8_Dataset Estrone.xlsx"}], "identifier": "https://doi.org/10.23719/1369435", "keyword": ["adverse outcome pathway", "aquatic ecosystems", "ecotoxicology", "endocrine disruption", "environmental estrogens", "estradiol", "estrone", "screening and prioritization"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2017-07-13", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1021/acs.est.7b00606"], "rights": null, "title": "Conversion of environmental estrone to estradiol by male fathead minnows"}