{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Urmila Kodavanti", "hasEmail": "mailto:kodavanti.urmila@epa.gov"}, "description": "we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0.01-mg/kg/day; intraperitoneal) for 1-month to determine if suppression of glucocorticoid signaling was linked to adaptation. Vehicle- and dexamethasone-treated rats were exposed to air or 0.8-ppm ozone, 4 hours/dayx2 or 4 days to assess the impacts of acute exposure and adaptation, respectively. \n\nThis dataset is associated with the following publication:\nHeinriquez, A., S. Snow, J. Dye, M.C. Schladweiler, D. Alewel, C. Miller, and U. Kodavanti. The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats.   TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 447(116085): 1, (2022).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528281/Science%20Hub%20Version%20To%20Urmila%2006%2006%202022.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Science Hub Version To Urmila 06 06 2022.xlsx"}], "identifier": "https://doi.org/10.23719/1528281", "keyword": ["Nitrogen and Co-pollutants", "Ozone", "Stress hormones", "adaptation", "neuroendocrine"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2022-11-15", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.taap.2022.116085"], "rights": null, "title": "The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats"}