{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "To determine whether IL-4 is therapeutic in treating established\n\t\t\t experimental arthritis, a recombinant adenovirus carrying the gene that encodes\n\t\t\t murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle\n\t\t\t joints into mice with established collagen-induced arthritis (CIA).\n\t\t\t Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of\n\t\t\t arthritis and joint swelling compared with saline- and adenoviral control\n\t\t\t groups. Local expression of IL-4 also reduced macroscopic signs of joint\n\t\t\t inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind\n\t\t\t ankle joints resulted in a decrease in disease severity in the untreated front\n\t\t\t paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4\n\t\t\t resulted in a significant reduction in the severity of early-stage\n\t\t\t arthritis.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17812/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/25vc-57bg", "issued": "2025-07-13", "keyword": ["collagen-induced-arthritis", "gene-therapy", "interleukin-4", "murine-model", "nih"], "landingPage": "https://healthdata.gov/d/25vc-57bg", "modified": "2025-09-06", "programCode": ["009:048"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Gene therapy for established murine collagen-induced arthritis by\n\t\t  local and systemic adenovirus-mediated delivery of interleukin-4"}