{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Steven Simmons", "hasEmail": "mailto:simmons.steve@epa.gov"}, "description": "These are the raw data files for TOXSCI manuscript 19-0578 entitled, \u201cRespirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries\u201d:\nDescription from readme.txt file:\n\n1) sc_seahorse.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 1 single-concentration RSA screening of 1,042 Toxcast Phase I and II chemicals\n\n2) mc_seahorse.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 2 multi-concentration RSA screening of 249 actives from tier 1\n\n3) EFA.lvl0.merged.data.csv- contains all mapped raw OCR data from tier 3 EFA screening of 149 putative electron transport chain inhibitors\n\n4) mc5_mc6_ncct_mito_nov2019.csv- level 5 and 6 outputs from ToxCast pipeline (tcpl) analysis\n\n5) RawMC3_ToxCast_by_aeid.csv- level 3 tcpl outputs for all mitochondrial ToxCast assays\n\n6) RawMC5_ToxCast_by_aeid.csv- level 5 tcpl outputs for all mitochondrial ToxCast assays\n\n7) ref.set.chems.csv- sixty reference chemicals used to compared assay performance\n\n8) study_code.R- R script used to analyze data and generate figures and tables. \n\nThis dataset is associated with the following publication:\nHallinger, D., H. Lindsay, K. Friedman, D. Suarez, and S. Simmons. Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  176(1): 175-192, (2020).", "distribution": [{"accessURL": "https://doi.org/10.5061/dryad.zkh189367", "title": "https://doi.org/10.5061/dryad.zkh189367"}], "identifier": "https://doi.org/10.23719/1504436", "keyword": ["High throughput screening", "ToxCast"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2020-03-31", "programCode": ["020:095"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1093/toxsci/kfaa059", "https://doi.org/10.23645/epacomptox.12123735"], "rights": null, "title": "Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries"}