{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Leslie Thompson", "hasEmail": "mailto:thompson.leslie@epa.gov"}, "description": "we examined the cardiovascular effects acrolein inhalation, particularly on myocardial synchrony and performance via ultrasound echocardiography. Male C57Bl/6J mice (n=6/group) were exposed to filtered air (FA), 0.3 ppm acrolein, or 3.0 ppm acrolein for 3 hours in whole body plethysmography chambers. Cardiac strain data, heart function, and transmitral blood flow were investigated with echocardiography (40 MHz) 1 day prior to exposure, 1 hour after exposure, and 1 day after exposure. During the first 30 minutes of exposure, breathing frequency decreased. tidal volume increased, and expiratory/inspiratory time ratio increased in response to 3.0 ppm acrolein. Elapsed time between peak strain in adjacent wall segments (i.e. myocardial strain delay), a measure of myocardial dyssynchrony, increased significantly in mice exposed to 3.0 ppm acrolein at 1 and 24 hours post-exposure. Mice exposed to 0.3 ppm acrolein did not demonstrate changes in myocardial synchrony but did show decreases in myocardial performance, i.e. increased Tei index, at both 1 and 24 hours post-exposure. \n\nThis dataset is associated with the following publication:\nThompson, L., A. Ledbetter , N. Coates , W. Cascio , M. Hazari , and A. Farraj. Acrolein inhalation alters myocardial synchrony and performance at and below exposure concentrations that cause ventilatory responses.   Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 17(2): 97-108, (2017).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1427298/LT1%20Thompson%20et%20al%20Acrolein%20Study_Science%20Hub.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "LT1 Thompson et al Acrolein Study_Science Hub.xlsx"}], "identifier": "https://doi.org/10.23719/1427298", "keyword": ["Ambient air quality", "acrolein", "air pollution", "air quality", "echocardiography", "heart function", "myocardial dyssynchrony", "myocardial synchrony"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2018-03-20", "programCode": ["020:094"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1007/s12012-016-9360-4"], "rights": null, "title": "Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentration that Cause Ventilatory Responses in Mice"}