{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Marina Evans", "hasEmail": "mailto:evans.marina@epa.gov"}, "description": "This dataset describes disappearance of chloroform from a vapor uptake chamber with time due to metabolism. The research concentrates on optimization for estimation of metabolic constants using a novel technique. \n\nThis dataset is associated with the following publication:\nEvans, M., C. Eklund, D. williams, Y. Sey, and J. Simmons. Global Optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats.   INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 32(3): 97-109, (2020).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504242/EvansMarina_A-z35r_20190702.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "EvansMarina_A-z35r_20190702.xlsx"}], "identifier": "https://doi.org/10.23719/1504242", "keyword": ["Chloroform", "PBPK model", "vapor uptake inhalation"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2019-07-02", "programCode": ["020:096"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1080/08958378.2020.1742818"], "rights": null, "title": "Vapor uptake inhalation data for chloroform in F344 rats"}