{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "In the present study 55 IgVH genes amplified from three different\n\t\t\t anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding\n\t\t\t further information on synovial B-cell maturation and recirculation in RA. This\n\t\t\t analysis demonstrated somatically mutated IgVh genes in all regions studied,\n\t\t\t with amino acid deletions and mixed IgVh molecules, suggesting the existence of\n\t\t\t a novel pathway to generate (auto) antibody specificities. Comparison of amino\n\t\t\t acid sequences of amplified genes that belong to the VH1 family (with\n\t\t\t predominantly the same germline counterpart) exhibited strong homology,\n\t\t\t indicating an apparently conserved mutational pattern. This suggests that the\n\t\t\t number of antigens that activate B cells in different locations is restricted.\n\t\t\t The most striking result was the finding of clonally related sequences in\n\t\t\t different anatomical regions, indicating a recirculation of activated B cells\n\t\t\t between the different affected joints.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17813/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/qhc6-qfuw", "issued": "2025-07-13", "keyword": ["b-cell-recirculation", "igvh-genes", "nih", "rheumatoid-arthritis", "synovial-tissue"], "landingPage": "https://healthdata.gov/d/qhc6-qfuw", "modified": "2025-09-06", "programCode": ["009:048"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "IgVH genes from different anatomical regions, with different\n\t\t  histopathological patterns, of a rheumatoid arthritis patient suggest cyclic\n\t\t  re-entry of mature synovial B-cells in the hypermutation process"}