{
  "accessLevel": "public",
  "bureauCode": [
    "020:00"
  ],
  "contactPoint": {
    "fn": "Roman Mezencev",
    "hasEmail": "mailto:mezencev.roman@epa.gov"
  },
  "describedBy": "https://pasteur.epa.gov/uploads/10.23719/1504295/documents/Mezencev_Auerbach_Data_Dictionary.docx",
  "describedByType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
  "description": "This dataset is a project file generated by BMDExpress 2.2 SW  (Sciome, Research Triangle Park, NC). It contains gene expression data for livers of rats exposed to 4 chemicals (crude MCHM, neat MCHM, DMPT, p-toluidine) and kidneys of rats exposed to PPH. The project file includes normalized expression data (GeneChip Rat 230 2.0 Array) using 7 different pre-processing methods (RMA, GCRMA, MAS5.0, MAS5.0_noA calls, PLIER, PLIER16, and PLIER16_noA calls); differentially expressed probe-sets detected by William's method (p<0.05, and minimum fold change of 1.5); probeset-level and pathway-level BMD and BMDL values from transcriptomic dose-response modeling. \n\nThis dataset is associated with the following publication:\nMezencev, R., and S. Auerbach. The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization.   PLOS ONE. Public Library of Science, San Francisco, CA, USA, 15(5): e0232955, (2020).",
  "distribution": [
    {
      "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1504295/Mezencev_Auerbach_5_cmpds_7_normalizations_BMDExpress.zip",
      "mediaType": "application/x-zip-compressed",
      "title": "Mezencev_Auerbach_5_cmpds_7_normalizations_BMDExpress.zip"
    }
  ],
  "identifier": "https://doi.org/10.23719/1504295",
  "keyword": [
    "dose-response modeling",
    "microarray",
    "toxicogenomics"
  ],
  "license": "https://pasteur.epa.gov/license/sciencehub-license.html",
  "modified": "2018-08-30",
  "programCode": [
    "020:062"
  ],
  "publisher": {
    "name": "U.S. EPA Office of Research and Development (ORD)",
    "subOrganizationOf": {
      "name": "U.S. Environmental Protection Agency",
      "subOrganizationOf": {
        "name": "U.S. Government"
      }
    }
  },
  "references": [
    "https://doi.org/10.1371/journal.pone.0232955"
  ],
  "rights": null,
  "title": "The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization"
}