{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          A helium-oxygen gas mixture (heliox) has low gas density and low\n\t\t\t\tturbulence and resistance through narrowed airways. The effects of heliox on\n\t\t\t\tpulmonary mechanics following severe methacholine-induced bronchospasm were\n\t\t\t\tinvestigated and compared to those of a nitrogen-oxygen gas mixture (nitrox) in\n\t\t\t\tan innovative pediatric porcine, independent lung, mechanical ventilation\n\t\t\t\tmodel.\n        \n        \n          Results:\n          All of the lungs showed evidence of severe bronchospasm after\n\t\t\t\tmethacholine challenge. Prospective definition of 'heliox response'\n\t\t\t\twas a 15% or greater improvement in lung function in the lung receiving heliox\n\t\t\t\tcompared with the matched lung receiving nitrox. Seven out of 10 pigs responded\n\t\t\t\tto heliox therapy with respect to resistance and eight out of 10 pigs responded\n\t\t\t\tto heliox therapy with respect to compliance and tidal volume (P\n\t\t\t\t< 0.03). After crossover from nitrox to heliox, eight out of eight lungs\n\t\t\t\tsignificantly improved with respect to tidal volume, resistance and compliance\n\t\t\t\t(P < 0.001). After crossover from heliox to nitrox all eight lungs\n\t\t\t\tshowed a significant increase in resistance and a significant decrease in tidal\n\t\t\t\tvolume (P < 0.001).\n        \n        \n          Conclusions:\n          In a pediatric porcine model of acute, severe methacholine-induced\n\t\t\t\tbronchospasm and independent lung mechanical ventilation, administration of\n\t\t\t\theliox improves pulmonary mechanics, gas flow, and ventilation. Administration\n\t\t\t\tof heliox should be considered for support of pediatric patients with acute,\n\t\t\t\tsevere bronchospasm requiring mechanical ventilation through small artificial\n\t\t\t\tairways.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29016/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/ysus-tnrj", "issued": "2025-07-13", "keyword": ["heliox-therapy", "nih", "pediatric-bronchospasm", "porcine-model", "pulmonary-mechanics"], "landingPage": "https://healthdata.gov/d/ysus-tnrj", "modified": "2025-09-06", "programCode": ["009:048"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Heliox improves pulmonary mechanics in a pediatric porcine model of\n\t\t  induced severe bronchospasm and independent lung mechanical ventilation"}