{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Katie Friedman", "hasEmail": "mailto:paul-friedman.katie@epa.gov"}, "description": "Data for EPA collaboration with Case Western Reserve Univ, Erin Cohn, et al. 'Pervasive environmental chemicals impair oligodendrocyte development', DOI https://doi.org/10.1038/s41593-024-01599-2. \nPrimary screening results are available in Supplementary Table 1 and will be included in a future public release of the EPA ToxCast database. RNA-seq datasets generated in this study have been deposited in Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo) under accession code GSE244500. \n\nThis dataset is associated with the following publication:\nCohn, E., B. Clayton, M. Madhavan, K. Lee, S. Yacoub, Y. Fedorov  , M. Scavuzzo, K. Paul-Friedman, T. Shafer, and P. Tesar. Pervasive environmental chemicals impair oligodendrocyte development.   Nature Neuroscience. Nature Portfolio, Berlin,  GERMANY, 27(5): 836-845, (2024).", "distribution": [{"accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244500", "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244500"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%201-%20Primary%20screening%20results.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Supplementary Table 1- Primary screening results.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%202-%20ToxPrint%20enrichment%20analysis.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Supplementary Table 2- ToxPrint enrichment analysis.xlsx"}, {"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1530984/Supplementary%20Table%203-%20Gene%20set%20enrichment%20analysis.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Supplementary Table 3- Gene set enrichment analysis.xlsx"}], "identifier": "https://doi.org/10.23719/1530984", "keyword": ["cytotoxicity", "neurotoxicity", "oligodendrocytes", "screening"], "license": "https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html", "modified": "2024-01-23", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1038/s41593-024-01599-2", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088982"], "rights": null, "title": "Pervasive environmental chemicals impair oligodendrocyte development"}