{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "009:25"
  ],
  "contactPoint": {
    "@type": "vcard:Contact",
    "fn": "NIH/NCBI Data Team",
    "hasEmail": "mailto:info@ncbi.nlm.nih.gov"
  },
  "description": "Disclosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula <CHEM> wherein R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or <CHEM> wherein R4 and R5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula <CHEM> wherein R6 is loweralkyl of 1 to 4 carbon atoms; or R and R1, or R1 and R2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R1 or R2 must be other than hydrogen; and R3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula <CHEM> wherein m is 0, 1 or 2, p is 0 or 1, R7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R8 and R9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R8 and R9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan.",
  "distribution": [
    {
      "@type": "dcat:Distribution",
      "description": "Access the complete Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE. on the official website.",
      "downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E40115-T1",
      "mediaType": "text/html",
      "title": "Official Data Source"
    }
  ],
  "identifier": "https://healthdata.gov/api/views/duwj-qgb5",
  "issued": "2025-09-05",
  "keyword": [
    "chemistry",
    "innovation",
    "patent",
    "pubchem",
    "research"
  ],
  "landingPage": "https://healthdata.gov/d/duwj-qgb5",
  "modified": "2025-09-06",
  "programCode": [
    "009:066"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "National Center for Biotechnology Information (NCBI)"
  },
  "theme": [
    "NIH"
  ],
  "title": "Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE."
}