{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background:\n          Meconium aspiration syndrome (MAS) is still a condition associated\n\t\t\t\twith a high mortality, and many patients require extracorporeal membrane\n\t\t\t\toxygenation (ECMO) as rescue therapy. Beneficial effects of surfactant and\n\t\t\t\tperflubron lavage have been reported. However, pure surfactant supplementation\n\t\t\t\thas not been proven to be beneficial in the most severe forms of MAS. This\n\t\t\t\tstudy was performed to demonstrate an improvement in oxygenation in neonates\n\t\t\t\ttransferred for ECMO and fulfilling ECMO criteria with a saline lavage and\n\t\t\t\tsurfactant resupplementation.\n        \n        \n          Methods:\n          Twelve newborns with MAS [gestational age 36\u201340 weeks, mean birth\n\t\t\t\tweight 3200 g, age 4\u201316 h, oxygenation index (OI) > 40] transferred for ECMO\n\t\t\t\ttherapy were treated with saline lavage (5\u201310 cm3/kg body weight, as\n\t\t\t\tlong as green colored retrieval was observed) and resupplementation with bovine\n\t\t\t\tsurfactant (Alveofact, Boehringer, Ingelheim, Germany). The OI at admission and\n\t\t\t\t3 h after this procedure was compared using the t-test for paired\n\t\t\t\tsamples. ECMO was available as rescue therapy at all times.\n        \n        \n          Results:\n          The OI decreased from 49.4 (SD \u00b1 13.3) to 27.4 (SD \u00b1 7.3),\n\t\t\t\tP < 0.01. The decrease was sustained in nine patients, three\n\t\t\t\tpatients required ECMO and all patients survived.\n        \n        \n          Conclusions:\n          As MAS is a condition with parenchymal damage, pulmonary\n\t\t\t\thypertension and obstructive airway disease, no simple causative therapy is\n\t\t\t\tpossible. Surfactant application after removal of meconium by extensive lavage\n\t\t\t\tis feasible as long as 16 h after birth even in infants considered for ECMO\n\t\t\t\ttherapy; it might reduce the necessity of ECMO.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29009/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/xmdd-xq83", "issued": "2025-07-13", "keyword": ["bovine-surfactant", "ecmo-neonates", "meconium-aspiration", "nih", "saline-lavage"], "landingPage": "https://healthdata.gov/d/xmdd-xq83", "modified": "2025-09-06", "programCode": ["009:037"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Saline lavage with substitution of bovine surfactant in term neonates\n\t\t  with meconium aspiration syndrome (MAS) transferred for extracorporeal membrane\n\t\t  oxygenation (ECMO): a pilot study"}