{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Objective:\n          To assess the value of parameters derived from arterial blood gas\n\t\t\t\ttests in the diagnosis of pulmonary embolism.\n        \n        \n          Method:\n          We measured alveolar-arterial partial pressure of oxygen\n\t\t\t\t[P(A\u2013a)O2] gradient, PaO2 and arterial partial pressure\n\t\t\t\tof carbon diaxide (PaCO2) in 773 consecutive patients with suspected\n\t\t\t\tpulmonary embolism who were enrolled in the Prospective Investigative Study of\n\t\t\t\tAcute Pulmonary Embolism.\n        \n        \n          Diagnosis:\n          The study design required pulmonary angiography in all patients\n\t\t\t\twith abnormal perfusion scans.\n        \n        \n          Results:\n          Of 773 scans, 270 were classified as normal/near-normal and 503 as\n\t\t\t\tabnormal. Pulmonary embolism was diagnosed by pulmonary angiography in 312 of\n\t\t\t\t503 patients with abnormal scans. Of 312 patients with pulmonary embolism, 12,\n\t\t\t\t14 and 35% had normal P(A\u2013a)O2, PaO2 and\n\t\t\t\tPaCO2, respectively. Of 191 patients with abnormal scans and\n\t\t\t\tnegative angiograms, 11, 13 and 55% had normal P(A\u2013a)O2,\n\t\t\t\tPaO2 and PaCO2, respectively. The proportions of patients\n\t\t\t\twith normal/near-normal scans who had normal P(A\u2013a)O2,\n\t\t\t\tPaO2 and PaCO2 were 20, 25 and 37%, respectively. No\n\t\t\t\tdifferences were observed in the mean values of arterial blood gas data between\n\t\t\t\tpatients with pulmonary embolism and those who had abnormal scans and negative\n\t\t\t\tangiograms. Among the 773 patients with suspected pulmonary embolism, 364 (47%)\n\t\t\t\thad prior cardiopulmonary disease. Pulmonary embolism was diagnosed in 151\n\t\t\t\t(41%) of 364 patients with prior cardiopulmonary disease, and in 161 (39%) of\n\t\t\t\t409 patients without prior cardiopulmonary disease. Among patients with\n\t\t\t\tpulmonary embolism, there was no difference in arterial blood gas data between\n\t\t\t\tpatients with and those without prior CPD.\n        \n        \n          Conclusion:\n          These data indicate that arterial blood gas tests are of limited\n\t\t\t\tvalue in the diagnostic work-up of pulmonary embolism if they are not\n\t\t\t\tinterpreted in conjunction with clinical and other laboratory tests.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29023/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/dcuj-efri", "issued": "2025-07-13", "keyword": ["alveolar-arterial-gradient", "angiography", "blood-gas-analysis", "nih", "pulmonary-embolism"], "landingPage": "https://healthdata.gov/d/dcuj-efri", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Diagnostic value of gas exchange tests in patients with clinical\n\t\t  suspicion of pulmonary embolism"}