{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Urmila Kodavanti", "hasEmail": "mailto:kodavanti.urmila@epa.gov"}, "description": "Employing acrolein, a potent airway irritant, and TCE, with low irritancy, authors hypothesized that airway injury and inflammation would be involved in eliciting neuroendocrine-mediated systemic alterations. Male and female Wistar-Kyoto rats were exposed nose-only to air, acrolein or trichloroethylene (TCE) in incremental concentrations over 30 min, followed by 3.5-hr exposure to the highest concentration (acrolein - 0.0, 0.1, 0.316, 1, 3.16 ppm; TCE - 0.0, 3.16, 10, 31.6, 100 ppm) while performing head-out plethysmography (HOP), and animals were necropsied immediately post-exposure to assess nasal and lung injury/inflammation, systemic neurohormones, circulating stress hormones and also metabolic hormones. \n\nThis dataset is associated with the following publication:\nAlewel, D., T. Jackson, S. Vance, M. Schladweiler, P. Evansky, A. Henriquez, R. Grindstaff, S. Gavett, and U. Kodavanti. Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation.   TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 382: 22-32, (2023).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528189/Alewel%20et%20al_Toxicology_Sciencehub.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "Alewel et al_Toxicology_Sciencehub.xlsx"}], "identifier": "https://doi.org/10.23719/1528189", "keyword": ["Nitrogen and Co-pollutants", "acrolein", "air pollution", "ambient air", "sex difference", "trichloroethylene"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2022-11-07", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1016/j.toxlet.2023.05.005"], "rights": null, "title": "Sex-specific respiratory and systemic stress effects of acute acrolein and trichloroethylene inhalation"}