{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "026:00"
  ],
  "contactPoint": {
    "@type": "vcard:Contact",
    "fn": "Open Science Data Repository Help Desk",
    "hasEmail": "mailto:arc-dl-osdr-help@mail.nasa.gov"
  },
  "description": "In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due to age, twenty 12 week-old and twenty 29 week-old mice were flown, respectively. To directly assess spaceflight effects, half of the young and old mice (10 old, 10 young) were sacrificed on-orbit after 55-58 days (ISS Terminal, ISS-T), while the other half (10 old, 10 young) were returned live to Earth after 32 days and allowed to recover for 24 days (Live Animal Return, LAR) before sacrifice. ISS-T and LAR mice were the same age at sacrifice. Both the ISS-T and LAR animals had independent ground controls (GC; 10 mice per group housed in flight hardware in matched environmental conditions), basal controls (BSL; 10 mice per group sacrificed 2 days before launch), and vivarium controls (VIV; 10 mice per group housed within standard vivarium habitats). Thus RRRM-2 included a total of 160 mice. This study includes bulk RNA sequencing ribodepleted gene expression data from hearts from 5 old and 5 young animals from each of the following groups: LAR basal, LAR ground control, LAR vivarium control, LAR flight, ISS-T basal, ISS-T ground control, and ISS-T flight. The ISS-T vivarium control young group has only 3 animals due to quality control issues.",
  "distribution": [
    {
      "@type": "dcat:Distribution",
      "downloadURL": "http://purl.bioontology.org/ontology/NCBITAXON/10090",
      "format": "BIN",
      "mediaType": "application/octet-stream"
    },
    {
      "@type": "dcat:Distribution",
      "downloadURL": "https://nlsp.nasa.gov/view/lsdapub/lsda_experiment/46969989-6526-5a0f-8829-bed4bff9d331",
      "format": "BIN",
      "mediaType": "application/octet-stream"
    },
    {
      "@type": "dcat:Distribution",
      "downloadURL": "https://osdr.nasa.gov/bio/repo/data/missions/SpaceX-18",
      "format": "BIN",
      "mediaType": "application/octet-stream"
    },
    {
      "@type": "dcat:Distribution",
      "downloadURL": "https://osdr.nasa.gov/bio/repo/data/studies/OSD-580",
      "format": "BIN",
      "mediaType": "application/octet-stream"
    }
  ],
  "identifier": "10.26030/rrq0-wv29",
  "keyword": [
    "biological-and-physical-sciences",
    "genelab",
    "nasa"
  ],
  "license": "https://www.usa.gov/government-works",
  "modified": "2026-08-10",
  "programCode": [
    "026:000"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "Open Science Data Repository"
  },
  "theme": [
    "Biological and Physical Sciences"
  ],
  "title": "Transcriptional profiling of heart tissue from mice flown on the RRRM-2 mission"
}