{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Daniel Villeneuve", "hasEmail": "mailto:villeneuve.dan@epa.gov"}, "description": "The data set contains data for the following assays performed using 6PPD-quinone and/or 6PPD.  1) Larval fathead minnow transcriptomics; 2) larval fathead minnow EcoToxChips [6PPD-quinone only]; 3) zebrafish developmental and behavioral toxicity; 4) cell painting and cytotoxicity in the rainbow trout gill cell line, RTgill-W1; 5) acute and developmental neurotoxicity (DNT) assays in mammalian cells; 6) Attagene FACTORIAL assays with human hepatoma cells [6PPD-quinone only]; and 7) analytical assessment of 6PPD and 6PPD-quinone stability in RTgill-W1 and DNT assay media. \n\nThis dataset is associated with the following publication:\nJankowski, M., A. Carpenter, J. Harrill, D. Harris, B. Hill, R. Labiosa, S. Makarov, D. Martinovic-Weigelt, J. Nyffeler, S. Padilla, T. Shafer, M. Smeltz, and D. Villeneuve. Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  204(2): 198-217, (2025).", "distribution": [{"accessURL": "https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3", "title": "https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3"}], "identifier": "https://doi.org/10.23719/1531917", "keyword": ["Ambient Water", "New Approach Methods (Alternatives to Animal Testing)", "bioactivity", "chemicals", "computational toxicology"], "license": "https://pasteur.epa.gov/license/sciencehub-license.html", "modified": "2025-01-10", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1093/toxsci/kfaf008", "https://pasteur.epa.gov/uploads/10.23719/1531917/documents/Jankowski%20et%20al_Data%20availability%20summary.docx"], "rights": null, "title": "Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays"}