{"accessLevel": "public", "bureauCode": ["020:00"], "contactPoint": {"fn": "Jacqueline Bangma", "hasEmail": "mailto:bangma.jacqueline@epa.gov"}, "description": "These data represent underlying data generated for the study titled 'Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health'. Data include extracellular vesicle particle count and size distribution from nanoparticle tracking analysis; microRNA expression data from mRNA sequencing in extracellular vesicles; PFAS signature data from mass spectrometry analysis of isolated HepG2 cell lysates and their secreted extracellular vesicles; in vitro cell viability data. \n\nThis dataset is associated with the following publication:\nCarberry, C., J. Bangma, L. Koval, D. Keshava, h. Hartwell, M. Sokolsky, R. Fry, and J. Rager. Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved in liver health.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  197(2): 155-169, (2024).", "distribution": [{"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529913/PFASEVs_Tables.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "title": "PFASEVs_Tables.xlsx"}], "identifier": "https://doi.org/10.23719/1529913", "keyword": ["Mixtures", "PFAS", "extracellular vesicles", "liver toxicity"], "license": "https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html", "modified": "2023-02-16", "programCode": ["020:000"], "publisher": {"name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": {"name": "U.S. Environmental Protection Agency", "subOrganizationOf": {"name": "U.S. Government"}}}, "references": ["https://doi.org/10.1093/toxsci/kfad108", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823775"], "rights": null, "title": "Dataset for Extracellular Vesicles altered by Per- and Polyfluoroalkyl Substance Mixtures: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health."}