{
  "@type": "dcat:Dataset",
  "accessLevel": "public",
  "bureauCode": [
    "009:25"
  ],
  "contactPoint": {
    "@type": "vcard:Contact",
    "fn": "NIH",
    "hasEmail": "mailto:info@nih.gov"
  },
  "description": "To determine whether IL-4 is therapeutic in treating established\n\t\t\t experimental arthritis, a recombinant adenovirus carrying the gene that encodes\n\t\t\t murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle\n\t\t\t joints into mice with established collagen-induced arthritis (CIA).\n\t\t\t Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of\n\t\t\t arthritis and joint swelling compared with saline- and adenoviral control\n\t\t\t groups. Local expression of IL-4 also reduced macroscopic signs of joint\n\t\t\t inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind\n\t\t\t ankle joints resulted in a decrease in disease severity in the untreated front\n\t\t\t paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4\n\t\t\t resulted in a significant reduction in the severity of early-stage\n\t\t\t arthritis.",
  "distribution": [
    {
      "@type": "dcat:Distribution",
      "description": "Visit the original government dataset for complete information, documentation, and data access.",
      "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17812/",
      "mediaType": "text/html",
      "title": "Official Government Data Source"
    }
  ],
  "identifier": "https://healthdata.gov/api/views/25vc-57bg",
  "issued": "2025-07-13",
  "keyword": [
    "collagen-induced-arthritis",
    "gene-therapy",
    "interleukin-4",
    "murine-model",
    "nih"
  ],
  "landingPage": "https://healthdata.gov/d/25vc-57bg",
  "modified": "2025-09-06",
  "programCode": [
    "009:048"
  ],
  "publisher": {
    "@type": "org:Organization",
    "name": "National Institutes of Health"
  },
  "theme": [
    "NIH"
  ],
  "title": "Gene therapy for established murine collagen-induced arthritis by\n\t\t  local and systemic adenovirus-mediated delivery of interleukin-4"
}