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Federal
Read_Across_Prediction_of_Estrogenicity_for_Hindered_Phenols_2017_Data
U.S. Environmental Protection Agency —
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although... -
Federal
Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information
U.S. Environmental Protection Agency —
Read-across is a popular data gap filling technique within category and analogue approaches for regulatory purposes. Acceptance of read-across remains an ongoing... -
Federal
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
U.S. Environmental Protection Agency —
Data from a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity Prediction Project) demonstrating using predictive computational... -
Federal
Evaluating structure-based activity in a high-throughput assay for steroid biosynthesis
U.S. Environmental Protection Agency —
Dataset from Foster, M.J., et al., Evaluating structure-based activity in a high-throughput assay for steroid biosynthesis, Computational Toxicology, Vol 24, No.... -
Federal
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories
U.S. Environmental Protection Agency —
All of the code used to analyze and report the data as well as build confidence in the approach is available as a supplementary RMarkdown report, and a tool to derive... -
Federal
Investigation of pharmaceuticals in water, fish, and ospreys nesting in Delaware River and Bay
Department of the Interior —
Exposure of wildlife to Active Pharmaceutical Ingredients (APIs) is likely to occur but evidence of hazard and risk is limited. One exposure pathway that has received... -
Federal
Is Skin penetration a determining factor in skin sensitisation potential and potency? Refuting the notion of a LogKow threshold for Skin Sensitisation
U.S. Environmental Protection Agency —
t is widely accepted that substances that cannot penetrate through the skin will not be sensitizers. LogKow and molecular weight (MW) have been used to set thresholds... -
Federal
Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing
U.S. Environmental Protection Agency —
Data and code for "Grace Patlewicz, Ann M. Richard, Antony J. Williams, Richard S. Judson, Russell S. Thomas, Towards reproducible structure-based chemical categories... -
Federal
Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in read-across: A case study
U.S. Environmental Protection Agency —
Dataset for journal article "Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to... -
Federal
ToxCast bioactivity data for p,p'-DDD and analogues
U.S. Environmental Protection Agency —
Bioactivity data for p,p'-DDD and analogues from ToxCast assays conducted in liver cells were sourced from the EPA’s CompTox Chemistry Dashboard. The links also... -
Federal
ToxCast bioactivity data and model predictions for the ER and AR pathways for p,p'-DDD and analogues
U.S. Environmental Protection Agency —
ToxCast bioactivity data and model predictions for the estrogen receptor (ER) and androgen receptor (AR) pathways were obtained from the inks provided. This dataset... -
Federal
Generalised Read-Across (GenRA) refinements
U.S. Environmental Protection Agency —
These new analysis builds on the baseline GenRA approach and presents a proof of concept of how other contexts of similarity namely physchem can be implemented into a... -
Federal
Predicting Estrogenicity of a Group of Substituted Phenols_IATA
U.S. Environmental Protection Agency —
Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of... -
Federal
Exposure-response arrays for noncancer and cancer endpoints for p,p'-DDD and analogues
U.S. Environmental Protection Agency —
Data for the exposure-response arrays comparing effect levels for non-cancer and cancer endpoints for p,p'-DDD and analogues were sourced from the links provided.... -
Federal
Analogue search results for p,p'-DDD
U.S. Environmental Protection Agency —
The dataset contains the outputs for the analogue searches conducted for the chemical of interest, p,p'-DDD. This dataset is associated with the following... -
Federal
Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research
U.S. Environmental Protection Agency —
The original contributions presented in the study are included in the article and online through the TAME Toolkit, available at: https://uncsrp.github.io/Data-... -
Federal
Read-across application for emissions estimation
U.S. Environmental Protection Agency —
The emission data used is based on this publication. This dataset is associated with the following publication: Takkellapati, S., and M.A. Gonzalez. Application of...