31 datasets found
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Federal
microRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity
National Aeronautics and Space Administration —
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition simulated by a... -
Federal
Gene expression profiles of irradiated lung tissue in three mouse strains
National Aeronautics and Space Administration —
The aim of our research is to clarify the mechanisms generating heterogeneity in response to C-ion irradiation that arise from individual genetic variations in... -
Federal
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes
National Aeronautics and Space Administration —
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene... -
Federal
Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
National Aeronautics and Space Administration —
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body xce xb3 radiation and mammary glands were surgically removed 2-month after radiation.... -
Federal
Transcription profiling of activated human T cells induced by microgravity to identify apoptotic genes and other immune response genes
National Aeronautics and Space Administration —
The purpose of this study was to search for microgravity-sensitive genes specifically for apoptotic genes influenced by the microgravity environment and other genes... -
Federal
Densely Ionizing Radiation Effects on the Microenvironment Promote Aggressive Trp53 Null Mammary Carcinomas
National Aeronautics and Space Administration —
Densely ionizing radiation is a major component of the space radiation environment and has potentially greater carcinogenic effect compared to sparsely ionizing... -
Federal
Transcriptome Profiles in Normal Human Bronchial Epithelial Cells after Exposure to gamma-rays and different HZE particles
National Aeronautics and Space Administration —
Distinct transcriptome profiles in response to low-LET and high-LET and different radiation qualities of HZE particles. Total RNA obtained from HBEC3KT cells after 1... -
Federal
Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation
National Aeronautics and Space Administration —
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated... -
Federal
Worms spun in centrifuge at elevated g values
National Aeronautics and Space Administration —
Worms spun at higher than normal g values for 4 days on 20G centrifuge vs. worms kept at 1 X G. Both are mixed stage cultures. A stimulus or stress experiment design... -
Federal
Environmental and simulation facility conditions can modulate a behavioral-driven altered gravity response of Drosophila imagoes transcriptome
National Aeronautics and Space Administration —
Genome-wide transcriptional profiling shows that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene... -
Federal
Effect of a 91 day long stay in weightlessness on the International Space Station on mouse skin physiology
National Aeronautics and Space Administration —
Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in... -
Federal
Exposure of zebrafish larvae to 3g and 5g hyper gravity between 5-6 days post-fertilization.
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors with a special emphasis on bone formation. For this reason... -
Federal
Dynamic nature of epigenetic patterns observed during the Mars 520-d mission simulation
National Aeronautics and Space Administration —
Interplanetary human spaceflight represents a formidable medical challenge but also provides a unique platform for investigating human adaptation to extreme... -
Federal
The Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
National Aeronautics and Space Administration —
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients but with an accelerated timeframe. This... -
Federal
Effect of electromagnetic fields on the chondrogenic differentiation under microgravity conditions
National Aeronautics and Space Administration —
A combination therapy of electromagnetic fields (EMF) and simulated microgravity (SMG) has not been examined in regenerative medicine of cartilage. In the present... -
Federal
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
National Aeronautics and Space Administration —
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent... -
Federal
Candida albicans response to spaceflight (NASA STS-115)
National Aeronautics and Space Administration —
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen Candida albicans grown... -
Federal
Gene expression in blood of mice with internal exposure to Cs-137
National Aeronautics and Space Administration —
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled it can expose the entire body for an... -
Federal
Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival
National Aeronautics and Space Administration —
Saccharomyces cerevisiae flocculation occurs when fermentable sugars are limiting and is therefore considered as a way to enhance the survival chance of... -
Federal
Action of microgravity on root development
National Aeronautics and Space Administration —
Arabidopsis were grown on horizontal or vertical clinostat for 4 8 or 12 days. Seedlings on horizontal clinostat were in simulated microgravity and seedlings on...
31 datasets found