Four digital water-surface profile maps for a 14-mile reach of the Mississippi River near Prairie Island in Welch, Minnesota from the confluence of the St. Croix River at Prescott, Wisconsin to upstream of the United States Army Corps of Engineers (USACE) Lock and Dam No. 3 in Welch, Minnesota, were created by the U.S. Geological Survey (USGS) in cooperation with the Prairie Island Indian Community. The water-surface profile maps depict estimates of the areal extent and depth of inundation corresponding to selected water levels (stages) at the USGS streamgage Mississippi River at Prescott, Wisconsin (USGS station number 05344500). Current conditions for estimating near-real-time areas of water inundation by use of USGS streamgage information may be obtained on the internet at http://waterdata.usgs.gov/. Water-surface profiles were computed for the stream reach using HEC-GeoRAS software by means of a one-dimensional step-backwater HEC-RAS hydraulic model using the steady-state flow computation option. The hydraulic model used in this study was previously created by the USACE . The original hydraulic model previously created extended beyond the 14-mile reach used in this study. After obtaining the hydraulic model from USACE, the HEC-RAS model was calibrated by using the most current stage-discharge relations at the USGS streamgage Mississippi River at Prescott, Wisconsin (USGS station number 05344500). The hydraulic model was then used to determine four water-surface profiles for flood stages referenced to 37.00, 39.00, 40.00, and 41.00-feet of stage at the USGS streamgage on the Mississippi River at Prescott, Wisconsin (USGS station number 05344500). The simulated water-surface profiles were then combined with a digital elevation model (DEM, derived from light detection and ranging (LiDAR) in Geographic Information System (GIS) data having a 0.35-foot vertical and 1.97-foot root mean square error horizontal resolution) in order to delineate the area inundated at each stage. The calibrated hydraulic model used to produce digital water-surface profile maps near Prairie Island, as part of the associated report, is documented in the U.S. Geological Survey Scientific Investigations Report 2021-5018 (https://doi.org/10.3133/ sir20215018). The data provided in this data release contains three zip files: 1) MissRiverPI_DepthGrids.zip, 2) MissRiverPI_InundationLayers.zip, and 3) ModelArchive.zip. The MissRiverPI_DepthGrids.zip and MissRiverPI_InundationLayers.zip files contain model output water-surface profile maps as shapefiles (.shp) and Keyhole Markup Language files (.kmz) that can be opened using Esri GIS systems (.shp files) or Google Earth (.kmz files), while the ModelArchive.zip contains model inputs, outputs, and calibration data used in creating the water-surface profiles maps.