Vibrio population structure - Genetic and population structure analysis of clinical and environmental Vibrio parahaemolyticus strains

Metadata Updated: February 8, 2018

Vibrio parahaemolyticus (Vp) is a marine bacterium capable of causing severe gastroenteritis in humans, usually through the consumption of raw shellfish. Before 1995, Vp-vibriosis was sporadic world-wide and caused by a relatively heterogeneous population of the bacterium. Since then, outbreaks have become more epidemic, with foci of infections traced to seafood harvested from single or geographically-linked sites. While initial outbreaks in Asia (and later in South America and the U.S. Gulf Coast region) have been attributed to a single serotypically-related pandemic clonal complex, other serotypes have been implicated in distinct geographical areas, including the Pacific Northwest and Alaska in the U.S.

Current risk assessment models are based on the presence of the virulence-associated genes tdh and trh, yet illnesses have been attributed to tdh- and/or trh- isolates. Previous phylogenetic studies have shown that Vp, like most Vibrio spp., is a genetically diverse species, and as yet there has been no definitive conclusion as to what genes are essential for virulence. Using phenotypic, genetic, and genomic comparison methods such as Multi-Locus Sequence Typing (MLST), we are examining the hypothesis that a set of highly-virulent clones of Vp with increased pathogenic potential have recently emerged in the PNW, and determining whether the emergence can be correlated with specific environmental parameters. MLST and other genotyping analyses of clinical and environmental Vp isolates from PNW sources demonstrate the extensive patterns of diversity as seen elsewhere. However, the majority of PNW strains obtained from human infections form a distinct clonal complex separate from most environmental isolates. Interestingly, many environmental isolates obtained from PNW sources are phylogenetically related to the pandemic clonal complex, but this group has not been associated with clinical infections in the region. Genome sequences.

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Metadata Date April 5, 2017
Metadata Created Date September 27, 2015
Metadata Updated Date February 8, 2018
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Harvested from NOAA CSW Harvest Source

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Resource Type Dataset
Metadata Date April 5, 2017
Metadata Created Date September 27, 2015
Metadata Updated Date February 8, 2018
Reference Date(s) (publication)
Responsible Party (); Northwest Fisheries Science Center (Point of Contact, Custodian)
Contact Email
Access Constraints Access Constraints: NA | Use Constraints: Disclaimer - While every effort has been made to ensure that these data are accurate and reliable within the limits of the current state of the art, NOAA cannot assume liability for any damages caused by any errors or omissions in the data, nor as a result of the failure of the data to function on a particular system. NOAA makes no warranty, expressed or implied, nor does the fact of distribution constitute such a warranty.
Bbox East Long -122.2962
Bbox North Lat 47.6549
Bbox South Lat 47.6449
Bbox West Long -122.3062
Coupled Resource
Frequency Of Update
Guid gov.noaa.nmfs.inport:17957
Harvest Object Id d247d4c3-33ec-4463-80c4-d4fb9dff1fba
Harvest Source Id 2aed8e29-fc5b-4cde-aa66-fb1118fd705e
Harvest Source Title NOAA CSW Harvest Source
Metadata Language eng
Metadata Type geospatial
Progress onGoing
Spatial Data Service Type
Spatial Reference System
Spatial Harvester True
Temporal Extent Begin 2008-10-01
Temporal Extent End 2012-10-05

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