The northern Gulf of Mexico coast spans two major climate gradients and represents an excellent natural laboratory for developing climate-influenced ecological models. In this project, we used these zones of remarkable transition to develop macroclimate-based models for quantifying the regional responses of coastal wetland ecosystems to climate variation. In addition to providing important fish and wildlife habitat and supporting coastal food webs, these coastal wetlands provide many ecosystem goods and services including clean water, stable coastlines, food, recreational opportunities, and stored carbon. Our objective was to examine and forecast the effects of macroclimatic drivers on wetland ecosystem structure and function in the northern Gulf of Mexico.