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    • Transcriptomic analysis of spleens from mice subjected to chronic low-dose radiation hindlimb unloading or a combination of both

    Metadata Updated: December 7, 2023

    The purpose of this study was to evaluate transcriptional changes in mouse spleens using a ground-based model for spaceflight. This model includes prolonged unloading and low-dose irradiation. Low-dose-rate gamma-radiation was delivered to 6-month old female C57BL/6J mice using 57Co plates (0.04 Gy) to simulate the radiation environment of spaceflight. Anti-orthostatic tail suspension was used to model the unloading fluid shift and physiological stress aspects of the microgravity component of spaceflight. Mice were hindlimb suspended and/or irradiated for 21 days. Mice were euthanized and spleens collected 7 days following treatment. RNA sequencing data was generated to assess transcriptional changes in these spleens.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: us-pd

    Downloads & Resources

    Dates

    Metadata Created Date February 1, 2023
    Metadata Updated Date December 7, 2023
    Data Update Frequency irregular

    Metadata Source

    Harvested from NASA Data.json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date February 1, 2023
    Metadata Updated Date December 7, 2023
    Publisher National Aeronautics and Space Administration
    Maintainer
    Identifier nasa_genelab_GLDS-211_ye6w-xar9
    Data First Published 2021-05-21
    Data Last Modified 2023-01-26
    Category Earth Science
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://data.nasa.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 9bd2aa84-2e46-413d-af9a-330ec376a484
    Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
    Harvest Source Title NASA Data.json
    Homepage URL https://data.nasa.gov/d/ye6w-xar9
    License http://www.usa.gov/publicdomain/label/1.0/
    Program Code 026:005
    Source Datajson Identifier True
    Source Hash 36f3940374d09b7170b0173557cb45ec4aa94b4407e9f739d03c1f2e7a233ddc
    Source Schema Version 1.1

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