Transcriptional profiling of mammary glands from mice flown on the RRRM-1 mission
In Rodent Research Reference Mission-1 (RRRM-1), also known as RR-8, forty female BALB/cAnNTac mice were flown on the International Space Station. To assess differences in outcomes due to age, twenty 10-12 week-old and twenty 32 week-old mice were flown, respectively. To directly assess spaceflight effects, half of the young and old mice (10 old, 10 young) were sacrificed on-orbit after 22-23 days (ISS Terminal, ISS-T), while the other half (10 old, 10 young) were returned live to Earth after 40 days and allowed to recover for 2 days (Live Animal Return, LAR) before sacrifice. Both the ISS-T and LAR animals had independent ground controls (10 mice housed in flight hardware in matched environmental conditions), basal controls (10 mice sacrificed 1 day after launch), and vivarium controls (10 mice housed within standard vivarium habitats). Thus RRRM-1 included a total of 160 mice. This datasets features ribodepleted total RNA-seq data from mammary glands dissected from six LAR groups (young and old for flight, ground control, and vivarium control). Data from 5-10 livers per group are included. All samples include either Mix 1 or Mix 2 of the ERCC spike-in control. Target depth was 60 M clusters sequenced at PE 150 bp.
Resources
4 resources available
-
Resource 1
BIN -
Resource 2
BIN -
Resource 3
BIN -
Resource 4
BIN
Find Related Datasets
Search by Tags
Click any tag below to search for similar datasets
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "026:00" ] |
| contactPoint |
{ "fn": "Open Science Data Repository Help Desk", "@type": "vcard:Contact", "hasEmail": "mailto:arc-dl-osdr-help@mail.nasa.gov" } |
| description | In Rodent Research Reference Mission-1 (RRRM-1), also known as RR-8, forty female BALB/cAnNTac mice were flown on the International Space Station. To assess differences in outcomes due to age, twenty 10-12 week-old and twenty 32 week-old mice were flown, respectively. To directly assess spaceflight effects, half of the young and old mice (10 old, 10 young) were sacrificed on-orbit after 22-23 days (ISS Terminal, ISS-T), while the other half (10 old, 10 young) were returned live to Earth after 40 days and allowed to recover for 2 days (Live Animal Return, LAR) before sacrifice. Both the ISS-T and LAR animals had independent ground controls (10 mice housed in flight hardware in matched environmental conditions), basal controls (10 mice sacrificed 1 day after launch), and vivarium controls (10 mice housed within standard vivarium habitats). Thus RRRM-1 included a total of 160 mice. This datasets features ribodepleted total RNA-seq data from mammary glands dissected from six LAR groups (young and old for flight, ground control, and vivarium control). Data from 5-10 livers per group are included. All samples include either Mix 1 or Mix 2 of the ERCC spike-in control. Target depth was 60 M clusters sequenced at PE 150 bp. |
| distribution |
[ { "@type": "dcat:Distribution", "format": "BIN", "mediaType": "application/octet-stream", "downloadURL": "http://purl.bioontology.org/ontology/NCBITAXON/10090" }, { "@type": "dcat:Distribution", "format": "BIN", "mediaType": "application/octet-stream", "downloadURL": "https://lsda.jsc.nasa.gov/Experiment/exper/27139" }, { "@type": "dcat:Distribution", "format": "BIN", "mediaType": "application/octet-stream", "downloadURL": "https://osdr.nasa.gov/bio/repo/data/missions/SpaceX-16" }, { "@type": "dcat:Distribution", "format": "BIN", "mediaType": "application/octet-stream", "downloadURL": "https://osdr.nasa.gov/bio/repo/data/studies/OSD-511" } ] |
| identifier | 10.26030/wdpr-va45 |
| keyword |
[ "__" ] |
| license | https://www.usa.gov/government-works |
| modified | 2026-06-22 |
| programCode |
[ "026:000" ] |
| publisher |
{ "name": "Open Science Data Repository", "@type": "org:Organization" } |
| theme |
[ "Biological and Physical Sciences" ] |
| title | Transcriptional profiling of mammary glands from mice flown on the RRRM-1 mission |
