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Synthetic biology assemblies for sustainable space exploration

Metadata Updated: November 12, 2020

The work utilized synthetic biology to create sustainable food production processes by developing technology to efficiently convert inedible crop waste to supplemental high-protein food. The technology is based on modular enzyme complexes incorporating components from different organisms that have been shown to convert inaccessible cellulosic biomass like crop waste to soluble sugars more efficiently than enzymes without structural scaffolding. Long-duration crewed mission beyond low earth orbit will require significant supplies of food and closure of waste loops.  Current crop growth systems produce approximately 50% inedible crop waste.  Unique NASA-developed synthetic biology assemblies employ biomimicry to improve on naturally occurring enzymatic cellulosomes.  These engineered enzyme complexes may be utlized to reduce crop waste by 50% and recover resources for food.Major constituents of crop waste include cellulose, hemicellulose and lignin.  Our bioengineered assemblies would significantly improve the conversion of these constitutents to sugars by eliminating the need for chemical pretreatment and reducing the large amount of enzymes typically required.  This will be accomplished by engineering synthetic cellulosomes for specifi ratios of cellulololytic enzymes that target these specific cellulosic components.The project completed a number of laboratory assays to compare enzymatic activity on a substrate of a select grouping of proteins attached to our synthetic cellulosome versus the activity unattached, in solution.  Selection of groups is based upon reported combinations of enzymes that occur natually in the cellulosome.  

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Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher Space Technology Mission Directorate
Unique Identifier Unknown
Identifier TECHPORT_10637
Data First Published 2012-01-01
Data Last Modified 2020-01-29
Public Access Level public
Bureau Code 026:00
Metadata Context
Metadata Catalog ID
Schema Version
Catalog Describedby
Harvest Object Id 18795f28-3a27-4ef1-9056-ee94fa71d287
Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
Harvest Source Title NASA Data.json
Homepage URL
Program Code 026:027
Source Datajson Identifier True
Source Hash ac992c1bb0197758566138682c9d8b6f2685c36b
Source Schema Version 1.1

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