Synthetic biology assemblies for sustainable space exploration

Metadata Updated: February 28, 2019

The work utilized synthetic biology to create sustainable food production processes by developing technology to efficiently convert inedible crop waste to supplemental high-protein food. The technology is based on modular enzyme complexes incorporating components from different organisms that have been shown to convert inaccessible cellulosic biomass like crop waste to soluble sugars more efficiently than enzymes without structural scaffolding. Long-duration crewed mission beyond low earth orbit will require significant supplies of food and closure of waste loops.[HTML_REMOVED] Current crop growth systems produce approximately 50% inedible crop waste.[HTML_REMOVED] Unique NASA-developed synthetic biology assemblies employ biomimicry to improve on naturally occurring enzymatic cellulosomes.[HTML_REMOVED] These engineered enzyme complexes may be utlized to reduce crop waste by 50% and recover resources for food.Major constituents of crop waste include cellulose, hemicellulose and lignin.[HTML_REMOVED] Our bioengineered assemblies would significantly improve the conversion of these constitutents to sugars by eliminating the need for chemical pretreatment and reducing the large amount of enzymes typically required.[HTML_REMOVED] This will be accomplished by engineering synthetic cellulosomes for specifi ratios of cellulololytic enzymes that target these specific cellulosic components.The project completed a number of laboratory assays to compare enzymatic activity on a substrate of a select grouping of proteins attached to our synthetic cellulosome versus the activity unattached, in solution.[HTML_REMOVED] Selection of groups is based upon reported combinations of enzymes that occur natually in the cellulosome.[HTML_REMOVED][HTML_REMOVED]

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Public: This dataset is intended for public access and use. License: U.S. Government Work

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Metadata Created Date August 1, 2018
Metadata Updated Date February 28, 2019

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date August 1, 2018
Metadata Updated Date February 28, 2019
Publisher Space Technology Mission Directorate
Unique Identifier TECHPORT_10637
Maintainer Email
Public Access Level public
Bureau Code 026:00
Metadata Context
Metadata Catalog ID
Schema Version
Catalog Describedby
Harvest Object Id dafe2b46-cc68-4c70-bcc4-89e585161fc7
Harvest Source Id 39e4ad2a-47ca-4507-8258-852babd0fd99
Harvest Source Title NASA Data.json
Data First Published 2012-01-01
Homepage URL
Data Last Modified 2018-07-19
Program Code 026:027
Source Datajson Identifier True
Source Hash 2d2c7f2535ef91a8aac5ce68419f80e2a656901d
Source Schema Version 1.1

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