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    • Supplementary data for "Distributions of fitness effects for amino acid changes from high-throughout mutagenesis experiments" (McCandlish and Stoltzfus, 2018)

    Metadata Updated: September 30, 2025

    McCandlish and Stoltzfus gathered data from deep mutational scanning experiments on 12 proteins, comprising 56641 distinct amino acid replacement mutations. By converting fitnesses to within-study quantiles, they combined results from all studies to draw general conclusions about distributions of fitness effects for the 380 different types of possible amino acid changes in proteins. They found that most replacements are neither conservative nor radical, but barely different from the background distribution. The shapes of these distributions can be approximated by a maximum-entropy model with only 1 parameter. This data package makes it possible to reproduce the main calculations used by Stoltzfus and McCandlish. The data also may be useful to researchers carrying out meta-analyses of mutation-scanning experiments or DFE experiments.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

    Downloads & Resources

    Dates

    Metadata Created Date November 12, 2020
    Metadata Updated Date September 30, 2025

    Metadata Source

    Harvested from Commerce Non Spatial Data.json Harvest Source

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date November 12, 2020
    Metadata Updated Date September 30, 2025
    Publisher National Institute of Standards and Technology
    Maintainer
    Identifier 762AD4DA63D05927E05324570681D36C1970
    Language en
    Data Last Modified 2018-09-18 00:00:00
    Category Mathematics and Statistics:Numerical methods and software, Chemistry:Molecular characterization, Bioscience:Engineering/synthetic biology
    Public Access Level public
    Bureau Code 006:55
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Data Dictionary https://data.nist.gov/od/ds/762AD4DA63D05927E05324570681D36C1970/README.md
    Harvest Object Id 0da9c9c0-db7f-492f-adaf-009f722d61c5
    Harvest Source Id bce99b55-29c1-47be-b214-b8e71e9180b1
    Harvest Source Title Commerce Non Spatial Data.json Harvest Source
    Homepage URL https://data.nist.gov/od/id/762AD4DA63D05927E05324570681D36C1970
    License https://www.nist.gov/open/license
    Program Code 006:045
    Source Datajson Identifier True
    Source Hash 3dfcd0fd106795cc4b55f4b4b66bae476292bde812d9445bab59e4e6cccd4a60
    Source Schema Version 1.1

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