These data are high-resolution bathymetry (riverbed elevation) and depth-averaged velocities in ASCII format, generated from hydrographic and velocimetric surveys of the Mississippi River near structure A5076 on Missouri State Highway 34 at Cape Girardeau, Missouri, in 2014 and 2018. Hydrographic data were collected using a high-resolution multibeam echosounder mapping system (MBMS), which consists of a multibeam echosounder (MBES) and an inertial navigation system (INS) mounted on a marine survey vessel. Data were collected as the vessel traversed the river along planned survey lines distributed throughout the reach. Data collection software integrated and stored the depth data from the MBES and the horizontal and vertical position and attitude data of the vessel from the INS in real time. Data processing required computer software to extract bathymetry data from the raw data files and to summarize and map the information. Velocity data were collected using an acoustic Doppler current profiler (ADCP) mounted on a survey vessel equipped with a differential global positioning system (DGPS). Data were collected as the vessel traversed the river along planned transect lines distributed throughout the reach. Velocity data were processed using the Velocity Mapping Toolbox (Parsons and others, 2013), and smoothed using neighboring nodes.