Skip to main content
U.S. flag

An official website of the United States government

Silica disrupts iron homeostasis in alveolar macrophages to impact a biological effect

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: April 21, 2026 at 07:59 PM | Dataset Last Updated: November 29, 2018
Cell investigation into mechanism of particle-related biological effect. This dataset is associated with the following publication: Ghio, A., J. Soukup, J. Stonehuerner , H. Tong, J. Richards, M. Gilmour, M. Madden, Z. Shen, and S.P. Kantrow. Quartz disrupts iron homeostasis in alveolar macrophages to impact a pro-inflammatory effect. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, USA, 32(9): 1737-1747, (2019).

Resources

21 resources available

  • kantrow figure 1a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 1b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 1d.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 1e.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 2A.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 3a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 3b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 3c.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 3d.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 4a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 4b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 4c.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 4d.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 5a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 5b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 6a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 6b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 6c.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 7a.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 7b.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

  • kantrow figure 7c.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
    Download

Find Related Datasets

Search by Tags

Click any tag below to search for similar datasets

Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
                                            [
  "020:00"
]
contactPoint 
                                            {
  "fn": "Andrew Ghio",
  "hasEmail": "mailto:ghio.andy@epa.gov"
}
description Cell investigation into mechanism of particle-related biological effect. This dataset is associated with the following publication: Ghio, A., J. Soukup, J. Stonehuerner , H. Tong, J. Richards, M. Gilmour, M. Madden, Z. Shen, and S.P. Kantrow. Quartz disrupts iron homeostasis in alveolar macrophages to impact a pro-inflammatory effect. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, USA, 32(9): 1737-1747, (2019).
distribution 
                                            [
  {
    "title": "kantrow figure 1a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%201a.xlsx"
  },
  {
    "title": "kantrow figure 1b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%201b.xlsx"
  },
  {
    "title": "kantrow figure 1d.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%201d.xlsx"
  },
  {
    "title": "kantrow figure 1e.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%201e.xlsx"
  },
  {
    "title": "kantrow figure 2A.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%202A.xlsx"
  },
  {
    "title": "kantrow figure 3a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%203a.xlsx"
  },
  {
    "title": "kantrow figure 3b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%203b.xlsx"
  },
  {
    "title": "kantrow figure 3c.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%203c.xlsx"
  },
  {
    "title": "kantrow figure 3d.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%203d.xlsx"
  },
  {
    "title": "kantrow figure 4a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%204a.xlsx"
  },
  {
    "title": "kantrow figure 4b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%204b.xlsx"
  },
  {
    "title": "kantrow figure 4c.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%204c.xlsx"
  },
  {
    "title": "kantrow figure 4d.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%204d.xlsx"
  },
  {
    "title": "kantrow figure 5a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%205a.xlsx"
  },
  {
    "title": "kantrow figure 5b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%205b.xlsx"
  },
  {
    "title": "kantrow figure 6a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%206a.xlsx"
  },
  {
    "title": "kantrow figure 6b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%206b.xlsx"
  },
  {
    "title": "kantrow figure 6c.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%206c.xlsx"
  },
  {
    "title": "kantrow figure 7a.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%207a.xlsx"
  },
  {
    "title": "kantrow figure 7b.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%207b.xlsx"
  },
  {
    "title": "kantrow figure 7c.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1503077/kantrow%20figure%207c.xlsx"
  }
]
identifier https://doi.org/10.23719/1503077
keyword 
                                            [
  "particulate matter (PM)"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2018-11-29
programCode 
                                            [
  "020:000"
]
publisher 
                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
                                            [
  "https://doi.org/10.1021/acs.chemrestox.8b00301"
]
rights 
                                            null
title Silica disrupts iron homeostasis in alveolar macrophages to impact a biological effect

data.gov

An official website of the GSA's Technology Transformation Services

Looking for U.S. government information and services?
Visit USA.gov