Tabular data output from a series of groundwater modeling simulations for five counties along the Central Coast of California, USA. We used a spatially explicit state-and-transition simulation model with stocks and flows that integrates climate, land-use change, human water use, and groundwater gain-loss to examine the impact of future climate and land use change on groundwater balance and water demand at 270-m resolution from 2010 to 2060. The model incorporated downscaled groundwater recharge projections based on a Warm/Wet and a Hot/Dry climate future using output from the Basin Characterization Model, a spatially explicit hydrological process-based model. Two urbanization projections from a parcel-based, regional urban growth model representing 1) recent historical and 2) state-mandated housing growth projections were used as alternative spatial targets for future urban growth. Agricultural projections were based on recent historical trends from remote sensing data. Annual projected changes in groundwater balance were calculated as the difference between land-use related water demand, based on historical estimates, and climate-driven recharge plus agriculture return flows to groundwater from excess irrigation. For each combination of the two climate and two land-use change scenarios, we ran 50 Monte Carlo realizations of the model. Results presented here have been aggregated from the individual cell level and summarized by county.