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    • Patent AT-E401420-T1: [Translated] DNA DETECTION USING PRIMERS WHICH HYBRIDISE WITH NON-FRAGMENTED DNA

    Metadata Updated: September 8, 2025

    The present invention provides a method of detecting non-apoptotic DNA in clinical samples. In particular there is provided a novel screening methodology for the detection of colorectal carcinoma. Cancer results from genetic mutations which result in uncontrolled and unregulated cell growth. Apoptosis does not occur in cancerous cells and thus the DNA remains unfragmented. Colorectal cancer results from mutations which occur in varying sites of the DNA. Accordingly there is no ubiquitous marker specific to colorectal tumour cells. The present invention provides the finding that the presence of specific fragments of DNA can be used to diagnose cancer irrespective of the point of DNA mutation. The method includes the step of obtaining a suitable sample, extracting the DNA therefrom and then amplifying and separating the fragments by electrophoresis in order to detect the presence of banding which is indicative of non-fragmented DNA derived from cancerous cells.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date September 7, 2025
    Metadata Updated Date September 8, 2025

    Metadata Source

    Harvested from Healthdata.gov

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date September 7, 2025
    Metadata Updated Date September 8, 2025
    Publisher National Center for Biotechnology Information (NCBI)
    Maintainer
    Identifier https://healthdata.gov/api/views/r433-sb9g
    Data First Published 2025-09-05
    Data Last Modified 2025-09-06
    Category NIH
    Public Access Level public
    Bureau Code 009:25
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://healthdata.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 119b607d-a234-4a40-b910-ca83c3bf62b2
    Harvest Source Id 651e43b2-321c-4e4c-b86a-835cfc342cb0
    Harvest Source Title Healthdata.gov
    Homepage URL https://healthdata.gov/d/r433-sb9g
    Program Code 009:066
    Source Datajson Identifier True
    Source Hash 722a5d859a29692d5d634423a5dd58b2327ecd2b1cf580a3fbac7332918032a5
    Source Schema Version 1.1

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