On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS), Phase I

Metadata Updated: August 1, 2018

Aurora Flight Sciences Corporation and our partner, Draper Laboratory, propose to develop an on orbit immuno-based, label-free, white blood cell counting system for simultaneous counting of peripheral blood cell subpopulations, including total white blood cells, the five white blood cell differential subgroups, and various lymphocyte subtypes, such as CD4 and CD8 positive cells, using Draper's MicroElectroMechanical Sensor (MEMS) based microfabricated arrayable Adhesive Stress Electrostatic Sensor (ASES) technology. The proposed ASES sensor uses a capacitance read-out method to electronically measure the sensor membrane displacement due to the surface stress caused by molecular binding, (e.g., antibody-antigen binding). Antibodies specific to the white blood cell surface protein markers (antigens) are precoated on the ASES sensor membrane to recognize the specific white blood cell types with inherently high specificity and sensitivity. Our proposed cell counting system can meet NASA's requirements for a microgravity compatible, miniaturized, light weight peripheral blood cell counting instrument capable of on-orbit cell counting, without high energy lasers, requiring minimal sample volume or exogenous (sheath) fluid to operate, and generating minimal biohazardous waste. This ASES blood cell counting system, once developed, can stand alone for white blood cell differential and subtype count, or become a complimentary instrument to others available on-orbit.

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Public: This dataset is intended for public access and use. License: U.S. Government Work

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Metadata Created Date August 1, 2018
Metadata Updated Date August 1, 2018

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Harvested from NASA Data.json

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Resource Type Dataset
Metadata Created Date August 1, 2018
Metadata Updated Date August 1, 2018
Publisher Space Technology Mission Directorate
Unique Identifier TECHPORT_8249
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TECHPORT SUPPORT
Maintainer Email
Public Access Level public
Bureau Code 026:00
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Harvest Source Title NASA Data.json
Data First Published 2009-07-01T07:00:00.000Z
Homepage URL https://techport.nasa.gov/view/8249
Language en-US
License http://www.usa.gov/publicdomain/label/1.0/
Data Last Modified 2017-09-16T00:00:00.000Z
Program Code 026:027
Publisher Hierarchy National Aeronautics and Space Administration > Space Technology Mission Directorate
Source Datajson Identifier True
Source Hash b9213e322b2c48bc6aad3c08614bf54a86a6ceb1
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