On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS), Phase I

Metadata Updated: May 2, 2019

Aurora Flight Sciences Corporation and our partner, Draper Laboratory, propose to develop an on orbit immuno-based, label-free, white blood cell counting system for simultaneous counting of peripheral blood cell subpopulations, including total white blood cells, the five white blood cell differential subgroups, and various lymphocyte subtypes, such as CD4 and CD8 positive cells, using Draper's MicroElectroMechanical Sensor (MEMS) based microfabricated arrayable Adhesive Stress Electrostatic Sensor (ASES) technology. The proposed ASES sensor uses a capacitance read-out method to electronically measure the sensor membrane displacement due to the surface stress caused by molecular binding, (e.g., antibody-antigen binding). Antibodies specific to the white blood cell surface protein markers (antigens) are precoated on the ASES sensor membrane to recognize the specific white blood cell types with inherently high specificity and sensitivity. Our proposed cell counting system can meet NASA's requirements for a microgravity compatible, miniaturized, light weight peripheral blood cell counting instrument capable of on-orbit cell counting, without high energy lasers, requiring minimal sample volume or exogenous (sheath) fluid to operate, and generating minimal biohazardous waste. This ASES blood cell counting system, once developed, can stand alone for white blood cell differential and subtype count, or become a complimentary instrument to others available on-orbit.

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Public: This dataset is intended for public access and use. License: U.S. Government Work

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Metadata Created Date August 1, 2018
Metadata Updated Date May 2, 2019

Metadata Source

Harvested from NASA Data.json

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Resource Type Dataset
Metadata Created Date August 1, 2018
Metadata Updated Date May 2, 2019
Publisher Space Technology Mission Directorate
Unique Identifier TECHPORT_8249
Maintainer Email
Public Access Level public
Bureau Code 026:00
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Metadata Catalog ID https://data.nasa.gov/data.json
Schema Version https://project-open-data.cio.gov/v1.1/schema
Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
Datagov Dedupe Retained 20190501230127
Harvest Object Id 8e23ae21-1c3c-4392-8b48-8235ed7cd78c
Harvest Source Id 39e4ad2a-47ca-4507-8258-852babd0fd99
Harvest Source Title NASA Data.json
Data First Published 2009-07-01
Homepage URL https://techport.nasa.gov/view/8249
License http://www.usa.gov/publicdomain/label/1.0/
Data Last Modified 2018-07-19
Program Code 026:027
Source Datajson Identifier True
Source Hash a2f8555582d3dbee3bbae188d36e77ecfffc125f
Source Schema Version 1.1

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