New class of biological radioprotectors, Phase I

Metadata Updated: May 2, 2019

Space radiation is the major risk to the astronauts outside the Earth magnetosphere that cannot be eliminated by the existing radioprotectors. The ultimate goal of this proposal is to develop a new class of pharmacological agents for protection against space radiation using a new source of natural products ?potent cell survival factors produced by endosymbiotic and parasitic microorganisms. Induction of programmed cell death (apoptosis) occurring in radiosensitive tissues is one of the major determinants of radiation-induced failure of hematopoietic and digestive systems and other pathologies, including pathological changes in the nervous system. As a part of their survival strategy, endosymbiotic and parasitic microorganisms evolved to produce powerful anti-apoptotic factors suppressing cell death in infected tissues; such factors were found to be effective radioprotectors. CBLB-501 protein isolated from Salmonella belongs to this category; it provides complete rescue of mice from lethal doses of gamma radiation causing hematopoietic and gastrointestinal syndromes. The proposed program is aimed at developing CBLB-501 into a useful radioprotective agent. It includes: a) evaluation of the radioprotective properties of CBLB501 in the animal model system; and optimization of treatment regimens, (b) development of optimized structural derivatives of CBLB-501, and (c) design and evaluation of combinatorial therapies employing CBLB501 together with most efficient conventional radioprotectors.

Access & Use Information

Public: This dataset is intended for public access and use. License: U.S. Government Work

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Dates

Metadata Created Date August 1, 2018
Metadata Updated Date May 2, 2019

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date August 1, 2018
Metadata Updated Date May 2, 2019
Publisher Space Technology Mission Directorate
Unique Identifier TECHPORT_5795
Maintainer
TECHPORT SUPPORT
Maintainer Email
Public Access Level public
Bureau Code 026:00
Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
Metadata Catalog ID https://data.nasa.gov/data.json
Schema Version https://project-open-data.cio.gov/v1.1/schema
Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
Datagov Dedupe Retained 20190501230127
Harvest Object Id cb7c87c0-abc4-4ff7-909c-f79daa4e2cdf
Harvest Source Id 39e4ad2a-47ca-4507-8258-852babd0fd99
Harvest Source Title NASA Data.json
Data First Published 2004-07-01
Homepage URL https://techport.nasa.gov/view/5795
License http://www.usa.gov/publicdomain/label/1.0/
Data Last Modified 2018-07-19
Program Code 026:027
Source Datajson Identifier True
Source Hash 30d157c8731311227ad56d7a47ef21ee662d5bbb
Source Schema Version 1.1

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