Groundwater-quality data collected between 1993 and 2015 were compiled from the U.S. Geological Survey (USGS) National Water Information System (NWIS) database for 722 wells in the San Joaquin Valley (SJV). Groundwater-quality data retrieved included lab analyses of complete major ion data (calcium, magnesium, sodium, potassium, chloride, sulfate, nitrate, alkalinity, bicarbonate, carbonate, silica, and TDS) for 613 samples, and an additional 109 samples with measured values of specific conductance. Most of these wells were sampled as part of the California Groundwater Ambient Monitoring and Assessment (GAMA) Program Priority Basin Project or the USGS National Water Quality Assessment (NAWQA) Program. In addition to GW quality data, the dataset includes well depths, measured or interpolated water levels, summary land-use information, and a tritium-based groundwater age classification. Each well was assigned to a geospatial grid cell in one of six SJV regions (https://www.sciencebase.gov/catalog/item/5892423ee4b072a7ac145e06). These data support the following publication: Hansen, J.A., Jurgens, B.C, Fram, M.S., Quantifying Anthropogenic Contributions to Century-Scale Groundwater Salinity Changes, San Joaquin Valley, California, USA: Science of the Total Environment, vol. XX, no. X, pp. XX-XX, 2018.