Flow discharges were measured in the Des Plaines River from approximately river mile 286 to river mile 284 on October 19–21, 2015 using Teledyne Rio Grande 1200 kHz acoustic Doppler current profilers (ADCP). The data were georeferenced with differential GPS receivers with submeter accuracy. These flow discharge measurements were collected in support of the US Army Corps of Engineers Great Lakes and Mississippi River Interbasin Study (GLMRIS), and were concurrent with a dye-tracing study. The discharge measurements included here were collected in the following locations: immediately upstream, across, and immediately downstream of the NRG Energy Joliet Power Station right descending bank intake (North Intake) immediately upstream, across, and immediately downstream of the NRG Energy Joliet Power Station left descending bank intake (South Intake) immediately upstream, across, and immediately downstream of the NRG Energy Joliet Power Station right descending bank outfall (North Outfall) across the NRG Energy Joliet Power Station left descending bank outfall (South Outfall) ADCP data were collected and initially reviewed in the WinRiver II software. Final review of discharge measurements was completed using the QRev discharge computation and review software (Mueller, D. S., 2016). The output from QRev includes an XML document with the processed results, and is included here. A stylesheet (XLS) file is also included to enable easy viewing of the QRev processed results. Note that additional discharge measurements associated with the dye-tracing study were taken at the existing US Geological Gaging Station, Des Plaines River in Lock Channel at Rockdale, IL (05538020), and can be accessed with the links below. A KMZ archive containing the locations of the ADCP shiptracks for each discharge measurement are included, along with an associated metadata file. Mueller, D.S., 2016, QRev—Software for computation and quality assurance of acoustic Doppler current profiler moving-boat streamflow measurements—User’s manual for version 2.8: U.S. Geological Survey Open-File Report 2016–1052, 50 p., http://dx.doi.org/10.3133/ofr20161052.