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Human Iodotyrosine Deiodinase Inhibition Assay: Screening of ToxCast Phase 1_v2, Phase 2, and e1k Chemical Libraries

Metadata Updated: March 29, 2021

The excel spreadsheet contains the resultant data from an assay for chemical inhibition of human Iodotyrosine Deiodinase (IYD) enzyme activity screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries, as well as a few additional target chemicals from ToxCast Phase 3 library or used in assay development. Over 1,800 chemicals were tested in total. This data set includes the list of chemicals tested and the median, minimum, and maximum inhibition produced by each chemical when screened at target high concentration of 200 µM. 154 chemicals were further tested in concentration response, and the median, minimum, and maximum inhibition produced at each concentration for those chemicals are included. A model inhibitor (3-Nitro-L-Tyrosine) was included on each plate as a positive control, with concentration response data for those curves also included in the data set.

This dataset is associated with the following publication: Olker, J., J. Korte, J. Denny, J. Haselman, P. Hartig, M. Cardon, M. Hornung, and S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71: 105073, (2021).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

References

https://doi.org/10.1016/j.tiv.2020.105073

Dates

Metadata Created Date March 29, 2021
Metadata Updated Date March 29, 2021

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date March 29, 2021
Metadata Updated Date March 29, 2021
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1518772
Data Last Modified 2020-06-10
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id d993f3f6-2495-486d-94c6-9ad05ec2ac64
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1016/j.tiv.2020.105073
Source Datajson Identifier True
Source Hash d9a08ec6ec7fe1bf1fd8d46feef15b054f0d65a3
Source Schema Version 1.1

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