This high-throughput method will be useful in rapid evaluation of chemicals for nuclear receptor activity for multiple species of interest. The modular design of the assay also permits ready development of new versions of the assay targeting any species with a nuclear receptor having a known DNA sequence. Underlying data and supplemental information available from Attagene. This dataset is not publicly accessible because: The data were not collected by EPA and are hosted external to the agency. EPA role limited to interpreting and describing outcome of data generated. It can be accessed through the following means: Contact the corresponding author Sergei S. Makarov at Attagene, Inc., PO Box 12054, Research Triangle Park, NC 27709. Email smak@attagene.com. Format: Not available.

This dataset is associated with the following publication: Medvedev, A., L. Medvedeva, E. Martsen, M. Moeser, K. Gorman, B. Lin, B. Blackwell, D. Villeneuve, K. Houck, K. Crofton, and S. Makarov. Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 54(19): 12142-12153, (2020).