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Gene-metabolite network linked to inhibited bioenergetics in association with spaceflight induced loss of quadriceps muscle

Metadata Updated: December 6, 2023

Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading. Under the Rodent Research Program of NASA we assayed the genomic and metabolomics perturbations in the quadriceps of C57BL/6j male mice that lived on the spaceflight (FLT) or at Ground Control (CTR) for approximately four weeks. Wet weight of quadriceps were significantly reduced in FLT mice. Deep next generation sequencing and untargeted mass spectroscopic assay interrogated the gene-metabolite landscape of same tissues. A majority of top ranked differentially suppressed genes in FLT encode proteins from myosin or troponin family suggesting a sarcomere alteration in space. Significantly enriched gene-metabolite networks were found linked to saromeric integrity immune fitness and oxidative stress response; all inhibited in space as per in silico prediction. A significant loss of FLT mitochondrial DNA copy numbers underlined the energy deprivation associated with spaceflight induced stress and this hypothesis was reinforced by the omics analysis that showed inhibited networks related to protein lipid and carbohydrate metabolism and ATP synthesis and hydrolysis. Finally we reported a list of upstream regulators which could be targeted for next generation therapeutic intervention for the betterment of the musculoskeletal system in male mice subjected to chronic disuse.

Access & Use Information

Public: This dataset is intended for public access and use. License: us-pd

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Dates

Metadata Created Date January 31, 2023
Metadata Updated Date December 6, 2023
Data Update Frequency irregular

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date January 31, 2023
Metadata Updated Date December 6, 2023
Publisher National Aeronautics and Space Administration
Maintainer
Identifier nasa_genelab_GLDS-326_f9hk-ca9q
Data First Published 2021-05-21
Data Last Modified 2023-01-26
Category Earth Science
Public Access Level public
Data Update Frequency irregular
Bureau Code 026:00
Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
Metadata Catalog ID https://data.nasa.gov/data.json
Schema Version https://project-open-data.cio.gov/v1.1/schema
Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
Harvest Object Id d8f25953-02c7-432b-98ae-0f27ff356340
Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
Harvest Source Title NASA Data.json
Homepage URL https://data.nasa.gov/d/f9hk-ca9q
License http://www.usa.gov/publicdomain/label/1.0/
Program Code 026:005
Source Datajson Identifier True
Source Hash b2935e974afafaaa34783d6c2464b3fcb0b46f0ce7b7fcf55478f7d07293662c
Source Schema Version 1.1

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