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Effects of heavy particle irradiation and diet on object recognition memory in rats

Metadata Updated: August 30, 2025

On long-duration missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. Previous research using a ground-based model for exposure to cosmic rays has shown that exposure to heavy particles, such as 56Fe, disrupts spatial learning and memory measured using the Morris water maze. Maintaining rats on diets containing antioxidant phytochemicals for 2 weeks prior to irradiation ameliorated this deficit. The present experiments were designed to determine: (1) the generality of the particle-induced disruption of memory by examining the effects of exposure to 56Fe particles on object recognition memory; and (2) whether maintaining rats on these antioxidant diets for 2 weeks prior to irradiation would also ameliorate any potential deficit. The results showed that exposure to low doses of 56Fe particles does disrupt recognition memory and that maintaining rats on antioxidant diets containing blueberry and strawberry extract for only 2 weeks was effective in ameliorating the disruptive effects of irradiation. The results are discussed in terms of the mechanisms by which exposure to these particles may produce effects on neurocognitive performance. This study derives behavior results from the novel object recognition assay. The original data derived from this study by Rabin et al. was transformed and used as part of a predictive modeling study by Dr. Mora, Dr. Wyrobek, Dr. Ben Brown et al. The study files contain both the original data and the transformed data produced by both research teams. For questions regarding the original study data and methods/assays, please contact the original study investigator and publication author Dr. Bernard Rabin (rabin@umbc.edu). For questions about the predictive modeling data files or how they were generated, please contact Dr. Mora (animora@berkeley.edu).

Access & Use Information

Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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Dates

Metadata Created Date April 11, 2025
Metadata Updated Date August 30, 2025

Metadata Source

Harvested from NASA Data.json

Additional Metadata

Resource Type Dataset
Metadata Created Date April 11, 2025
Metadata Updated Date August 30, 2025
Publisher Open Science Data Repository
Maintainer
Identifier 10.26030/vks4-1039
Data Last Modified 2025-08-21
Category Biological and Physical Sciences
Public Access Level public
Bureau Code 026:00
Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
Schema Version https://project-open-data.cio.gov/v1.1/schema
Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
Harvest Object Id 2b8e2e6e-c9ab-4ab8-b45b-260d61740f18
Harvest Source Id 58f92550-7a01-4f00-b1b2-8dc953bd598f
Harvest Source Title NASA Data.json
Program Code 026:000
Source Datajson Identifier True
Source Hash c4a0f44c7cc5612b427bbc668f71c13dc3b88021f8f63a2c3bc07a44f02ce9fa
Source Schema Version 1.1

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