Here we provide Germany’s Deutsches Zentrum fu¨r Luft- und Raumfahrt (DLR) Earth Sensing Imaging Spectrometer (DESIS) and Italy’s ASI’s PRecursore IperSpettrale della Missione Applicativa (PRISMA) Derived Spectral Library of Agricultural Crops for California. It was developed using DESIS and PRISMA hyperspectral data acquired in August 2021 near Fresno, CA. The 4-bin DESIS image has 60 bands with approximately 10 nm bandwidths from 400 to 1000 nm and is available through the German Aerospace Center and Teledyne Brown (2022). The PRISMA image has 235 bands with 10-12 nm bandwidths from 400-2500 nm and is available through the Italian Space Agency (ASI) (2022). In these PRISMA data, two bands in the overlapping spectral region of the visible-near infrared sensor and the shortwave infrared sensor were removed, for a total of 233 bands. Both images were downloaded as surface reflectance products. Some DESIS bands contain negative values; the user can choose to discard these bands. The crop type data and confidence layer for the year 2021 can be accessed through the USDA National Agricultural Statistics Service (2022). The DESIS and PRISMA Derived Spectral Library of Agricultural Crops dataset characteristics are described below, with DESIS and PRISMA data provided in two separate CSV files. Each dataset contains information for 16,581 samples located where the two images overlap. The user should examine the data against the USDA NASS CDL 2021 layer and decide whether some samples should be discarded due to uncertainty in the crop class label.