Data from: Dataset on characterization of recombinant interleukin-23α, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining

Metadata Updated: February 21, 2020

The data herein is related to the research article entitled "Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex", where it is demonstrated that the chicken interleukin (IL)-23α, IL-12p40, and IL-23 complex regulates Th1, Th17, and Treg cytokine production through heterodimer receptors as well as a homodimer receptor consisting of IL-12Rβ1 and IL-23R, and activates the JAK/STAT signaling pathways. Here, the effects of the recombinant chicken IL-23α, IL-12p40, and IL-23 complex protein on cell proliferation and nitric oxide (NO) production in chicken macrophage (HD11) and CU91 T cell lines are evaluated. In addition, the expression of IL-6, IL-17A, and interferon-γ mRNA were upregulated in vivo and in vitro. Moreover, treatment with the chicken IL-23α, IL-12p40, and IL-23 complex activated phosphorylation of tyrosine and serine residues in JAK2, STAT1, TYK2, and SOCS1 in chicken cell lines.

Access & Use Information

Public: This dataset is intended for public access and use. License: Creative Commons CCZero

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Dates

Metadata Created Date February 21, 2020
Metadata Updated Date February 21, 2020

Metadata Source

Harvested from USDA JSON

Additional Metadata

Resource Type Dataset
Metadata Created Date February 21, 2020
Metadata Updated Date February 21, 2020
Publisher Agricultural Research Service
Unique Identifier 2d5ebe87-11e7-452a-aa84-b6bb5807519d
Maintainer
Hong, Yeong Ho
Maintainer Email
Public Access Level public
Bureau Code 005:18
Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
Schema Version https://project-open-data.cio.gov/v1.1/schema
Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
Harvest Object Id 23815fa3-9b67-48c4-8bbd-7938c9d16391
Harvest Source Id 50ca39af-9ddb-466d-8cf3-84d67a204346
Harvest Source Title USDA JSON
License https://creativecommons.org/publicdomain/zero/1.0/
Data Last Modified 2019-08-05
Program Code 005:040
Source Datajson Identifier True
Source Hash eed4778962f368fb2081e815c170ed5438ad4437
Source Schema Version 1.1

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