Data from: Dataset on characterization of recombinant interleukin-23α, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining

Metadata Updated: December 10, 2020

The data herein is related to the research article entitled "Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex", where it is demonstrated that the chicken interleukin (IL)-23α, IL-12p40, and IL-23 complex regulates Th1, Th17, and Treg cytokine production through heterodimer receptors as well as a homodimer receptor consisting of IL-12Rβ1 and IL-23R, and activates the JAK/STAT signaling pathways. Here, the effects of the recombinant chicken IL-23α, IL-12p40, and IL-23 complex protein on cell proliferation and nitric oxide (NO) production in chicken macrophage (HD11) and CU91 T cell lines are evaluated. In addition, the expression of IL-6, IL-17A, and interferon-γ mRNA were upregulated in vivo and in vitro. Moreover, treatment with the chicken IL-23α, IL-12p40, and IL-23 complex activated phosphorylation of tyrosine and serine residues in JAK2, STAT1, TYK2, and SOCS1 in chicken cell lines.

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Public: This dataset is intended for public access and use. License: Creative Commons CCZero

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Metadata Created Date December 10, 2020
Metadata Updated Date December 10, 2020

Metadata Source

Harvested from USDA JSON

Additional Metadata

Resource Type Dataset
Metadata Created Date December 10, 2020
Metadata Updated Date December 10, 2020
Publisher Agricultural Research Service
Unique Identifier Unknown
Identifier 2d5ebe87-11e7-452a-aa84-b6bb5807519d
Data Last Modified 2019-08-05
Public Access Level public
Bureau Code 005:18
Metadata Context
Schema Version
Catalog Describedby
Program Code 005:040
Source Datajson Identifier True
Source Hash eed4778962f368fb2081e815c170ed5438ad4437
Source Schema Version 1.1

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