Potential evapotranspiration (PET), and reference evapotranspiration (ETo) are estimated at an approximately 2-kilometer (approximately 0.019 degrees longitude and 0.018 degrees latitude) spatial resolution and daily time-step from January 1, 2021 to December 31, 2021 for the entire State of Florida. PET and ETo were computed on the basis of solar radiation, meteorological data (min/max temperature, min/max relative humidity, and mean wind speed at 2-meter height), and shortwave blue-sky albedo data. Solar radiation was computed from Geostationary Operational Environmental Satellite (GOES) sensor data; blue-sky albedo was computed from the Moderate Resolution Imaging Spectrometer (MODIS) MCD43A1 BRDF/Albedo data product; and interpolated meteorological data were obtained from weather stations maintained by the Florida Automated Weather Network (FAWN), the South Florida Water Management District (SFWMD), and the National Oceanic and Atmospheric Administration (NOAA). Open-source tools for managing the NetCDF files in this data release can be found at https://code.usgs.gov/jbellino/florida-goes-et.