Salinity and variability of salinity in shallow waters shape living resources and habitat within Gulf of Mexico estuaries. The salinity gradient is widely recognized as foundational in maintaining biological diversity and productivity of estuaries. A clear understanding of the factors controlling salinity and variability of salinity in estuarine surface waters is essential for proper stewardship and for sustaining ecological structure and function. Salinity data are collected by numerous Federal, State, and local agencies and universities as part of routine data collection programs. We used online databases to compile salinity data in Gulf of Mexico estuaries. The primary criteria for inclusion in the compilation were a lengthy record of continuous collection with data sondes of at least hourly intervals. Stations that represented full estuarine gradients, from fresh to saline, were prioritized. Data were compiled in separate spreadsheets for each State using comma-delimited formatting. For each State, a second spreadsheet provides information on each station. A few stations started collecting salinity as early as the mid-1980s. More stations came on line by the mid- to late 1990s. Starting in the late 2000s many more stations came on line.