These data are a compilation of 379 borehole temperature profiles collected during the period 1972 through 2018 for the Mesilla Basin, New Mexico. This dataset includes a comma-separated values file (Temperature Profile Index.csv) that serves as an index for the 379 text data files (.txt; with the file name corresponding to the “Well Name” in the index) that are included as a compressed (.zip) folder. Each data file contains header information that allows cross-referencing the sample location with other USGS databases and summarizes sample date, method of measurement, and the type of borehole. Following the header is a list of depths below ground surface with corresponding temperature measurements (a temperature profile) at the borehole location. The index file (Temperature Profile Index.csv) provides the location (latitude and longitude) and summary details for each of the measured boreholes.