This data release contains monthly and annual water-use estimates from the Aquaculture and Irrigation Water-Use Model version 1.0 for the Mississippi Alluvial Plain, April 1999 to October 2017. Aquaculture and irrigation estimates contained in this data release are representative of groundwater withdrawal for six different categories: aquaculture, cotton, corn, rice, soybeans, and all other crops. Contained in this data release are monthly and annual estimates by water-use category and monthly and annual total estimates. Monthly and annual totals are a summation of water use for aquaculture, cotton, corn, rice, soybeans, and all other crops, by month and by year. Also contained in this data release are lands permitted to withdraw groundwater from the Mississippi River Valley Alluvial Aquifer, flowmeter data from the Mississippi Department of Environmental Quality, and summary tables of the total irrigated acres for each water-use category and average withdrawal rates for each spatio-climatic region within the Mississippi Delta. Aquaculture and irrigation water-use estimates are included in this data release in two different formats: georeferenced TIFFs (GeoTIFFs) for simple viewing and geospatial operations and a network common data form (NetCDF) for use in modeling applications. Estimates are provided here in multiple forms: monthly estimates by use (GeoTIFF), monthly total estimates (GeoTIFF and NetCDF), annual estimates by use (GeoTIFF), annual total estimates (GeoTIFF and NetCDF), and total estimates by water year (NetCDF). All estimates are in units of cubic meters per square mile. First posted - January 2021; Revised - April 2021 (version 2.0)