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Federal
Exposure of zebrafish larvae to 3g and 5g hyper gravity between 5-6 days post-fertilization.
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors, with a special emphasis on bone formation. For this... -
Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Real-time quantitative PCR analysis of human cardiovascular progenitor cells flown aboard the International Space Station
National Aeronautics and Space Administration —
Adult and neonatal human cardiovacular progenitor cell clonal populations were flown aboard the ISS for 12 days prior to fixation in RNAprotect. Gene expression... -
Federal
HSFA2 functions in the physiological adaptation of undifferentiated plant cells to spaceflight microgravity environment
National Aeronautics and Space Administration —
The Heat Shock Factor A2 (HsfA2) as a part of the HSF network is essential to the plant s response to almost any environmental stress and to the cellular homeostatic... -
Federal
HARV replication of the BRIC-23 Bacillus subtilis spaceflight
National Aeronautics and Space Administration —
Previous spaceflight experiments using Bacillus subtilis have reported altered transcriptome profiles during spaceflight compared to matching ground samples. This... -
Federal
Effect of a 91 day long stay in weightlessness on the International Space Station on mouse skin physiology
National Aeronautics and Space Administration —
Comparative gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in... -
Federal
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU) microgravity in mice: retina transcriptomic and epigenomic data
National Aeronautics and Space Administration —
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose... -
Federal
Transcription profiling of rat keratinocytes exposed to a 56Fe ion beam
National Aeronautics and Space Administration —
The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a 56Fe ion beam Experiment Overall Design: The cells... -
Federal
Effects of 21 days of bedrest on human skeletal muscle gene expression
National Aeronautics and Space Administration —
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic... -
Federal
Muscle atrophy osteoporosis prevention in hibernating mammals
National Aeronautics and Space Administration —
Physical inactivity decreases the mechanical load on the skeleton which when prolonged leads to losses of muscle strength and bone mass in humans and most mammalian... -
Federal
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
National Aeronautics and Space Administration —
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of... -
Federal
Global DNA methylation profiling of radiation-induced rat mammary carcinomas
National Aeronautics and Space Administration —
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat... -
Federal
Hindlimb suspension and reloading study
National Aeronautics and Space Administration —
Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice 14 days -Hindlimb suspension for 7... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special... -
Federal
Dynamic gene expression response to altered gravity in human T cells (parabolic flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Response of the EPI-200 human 3-D skin model to high and low doses of protons
National Aeronautics and Space Administration —
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose... -
Federal
Effect of a 91 day long stay in weightlessness on the International Space Station on mouse skin physiology
National Aeronautics and Space Administration —
Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in... -
Federal
A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space
National Aeronautics and Space Administration —
Bacterial behavior has been observed to change during spaceflight. Higher final cell counts enhanced biofilm formation increased virulence and reduced susceptibility... -
Federal
Osteocytes transcriptome is altered during spaceflight
National Aeronautics and Space Administration —
Bone loss is one of the major health problems for astronauts during long-term spaceflight and for patients during prolonged bed rest or paralysis. Growing evidence... -
Federal
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis [Experiment 2]
National Aeronautics and Space Administration —
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses...